Title : What is the possible therapeutic effect of ginkgo biloba on gastric ulcer induced by ammonia in albino rats?
Gastric ulcer is worldwide disease. Helicobacter pylori is one of the most common chronic bacterial infections that induce chronic inflammation in the gastric mucosa, mediated by an array of pro-and inflammatory cytokines. The aim of this study was to investigate the possible therapeutic effects of ginkgo biloba extract on gastric ulcer induced by ammonium hydroxide in rats and the potential underlying mechanisms. The study was done on 32 adult male Wistar albino rats, divided equally into 4 groups; normal control, gastric ulcer induced group using 1ml of 1% NH4OH orally, untreated control rats were received 1% carboxymethyl cellulose daily for 14 days after induction of ulcer and treated rats received orally 200mg/kg ginkgo biloba once daily for 14 days after induction of ulcer. The study revealed administration of ammonia showed multiple gastric lesions; edema, hyperemia , hemorrhage and ulcers with significant increase in ulcer score, myeloperoxidase (MPO), interleukin-1β (IL1β) and significant decrease in reduced glutathione (GSH), mucus amount and gastric PH. After the administration of ginkgo biloba, there was improved in gastric lesions, with significant reduction of ulcer score, MPO, IL-1β and significant increase in GSH, mucus content and gastric PH. Moreover, collagen type I & IV were gradually increased in treated group.
Key Words: Gastric ulcer ; Helicobacter pylori ; ginkgo biloba