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2024 Speakers

Kowit Hengphasatporn

Kowit Hengphasatporn, Speaker at Plant Biotechnology Conferences
University of Tsukuba, Japan
Title : Insights into molecular metabolism of herbicide-resistant CYP81As through molecular docking and MM/GBSA analysis


The structural protein of heme-containing monooxygenases, the CYP81As family, was modeled and evaluated in terms of herbicide-resistant study. A molecular docking study revealed the possible binding conformation of QC/CYP81As. The molecular mechanism of QC in complex with CYP81As suggests that CYP81A12 could be the preferential protein target for the QC metabolite, which is congruent with the experimental study. Additionally, the essential binding amino acid and the influence of HEME for QC/CYP81As have been proposed through per-residue decomposition free energy calculation using the MM/GBSA method. The possible metabolism of QC is elucidated through the combination of experimental and computational studies.


Dr. Kowit Hengphasatporn studied Molecular evolution at Srinakharinwirot University, Bangkok, Thailand and graduated as M.Sc. in 2015. I earned a Ph.D. in Bioinformatics from Chulalongkorn University in Bangkok, Thailand, under the supervision of Prof. Thanyada Rungrotmongkol in 2019. Currently, I hold the position of Assistant Professor at the Center for Computational Sciences, University of Tsukuba, under the Prof. Yasuteru Shigeta laboratory. My expertise lies in employing cutting-edge computational techniques with a focus on Molecular Dynamics (MD) simulations and ab initio Quantum Chemistry (QM) methods that have become a powerful technique to explain and visualize biological events, including in plants at an atomistic level.

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