Title: Fibrillarin sinteny evolution and viral interactions

Enrique Castano de la Serna

Centro de Investigacion Cienfica de Yucatan, Mexico


Dr. Enrique Castano de la Serna, receive his Ph.D degree in 1997 from the department of Biochemistry and Biophysics from the University of Rochester, NY, USA. After one year postdoctoral in MCB at Harvard University in Boston, he did 4 Years of Postdoctoral fellow at the Mary Curie Research Institute in the field of transcription. In 2002 he started a position in the department of Biochemistry and Molecular Biology in the Centro de Investigacion Cienfica de Yucatan, Where he is currently a senior professor in Molecular Biology. He has publish 50 Research articles in index journals and has graduated 10 Ph.D students.


Fibrillarin known as a RNA methyl transferase that has recently been shown to also methylate Histone H2A. Besides the escential role in the cell, Fibrillarin is also highjack by several virus and it is required for their progression through the floem. Becourse of their relevance and its good level of protein conservation in almost all eukaryotic cells and all archea kingdom we check its evolution. Some plants have  had several duplications of  their genome and therefore several copies of this protein are present, however our results show the unexpected that their sinteny is maintain showing some interesting genes that have been kept during the different steps in evolution. Here we show its evolution through eukaryotic genomes as well as the changes in sequences that interact with virus